β-glucan
- A functional polymer consisting of glucose units bonded together by β-1,3 linkage
- Non-specific immune activating properties were discovered for the first time in the 1940s
- Activation of macrophages, natural killer cells, and neutrophils
- Enhancement of immune system by promoting secretion of cytokine
Naturence has the technology to manufacture high-purity β-glucan using strain Agrobacterium sp. R259
- Production of high purity β-glucan using microbial fermentation process (86% or more)
- Individually recognized ingredient for immune enhancement (β-glucan powder No.2020-10)
- Fermented using patented strains (Patent No. 0450277)
- Production of β-glucan through 180-hour fermentation
- Application of 34 ton large fermentator and fermentation monitoring system
- Safe and hygienic production at GMP certified facilities
- Separation of β-glucan using a centrifuge without using an organic solvent as an extracellular polysaccharide
Naturence β-glucan is a high-purity β-glucan produced by microbial fermentation and is a individual recognized Ingredient by the Ministry of Food and Drug Safety for immunological efficacy
- Non-specific immune response activity
- Improving immune function by promoting secretion of various cytokines
- As a result of clinical demonstraion, NK cell activity and cytokine IL-10 increase
Ingestion of β-glucan powder
Dendritic cells
Transmitting an antigen that has invaded the human body to T cells to initiate an immune response
Promotes the expression of cell surface molecules and intracellular messenger and activates dendritic cells
T cell
Types of immune cells responsible for cellular immunity and the main role of adaptive immunity
T cell proliferation and activation
Cytokine
The role of a mediator in the growth and differentiation of immune cells
Increase the production of various cytokines such as TNF-a, INF-y, IL-2, IL-12, etc
NK cell
Types of white blood cells responsible for innate immunity, and cells that directly attack infected abnormal cells and eliminate them
NK cell activation
in vitro
- Subjects : Bone Marrow-derived Dendritic Cells
- Treatment: β-glucan 100, 200 μg/ml
Induce immune activity in dendritic cells and promote Th1 type immune response
in vivo
- Subjects : Thymus and spleen tissue of a rats that ingested β-glucan
- Treatment : Ingestion of β-glucan 1 %, 5 %
Promotes cellular immune responses and increases the secretion of IL-6, IL-12
- Subjects : Inflammatory Bowel Disease-Induced mouse
- Treatment : Ingestion of β-glucan 2.5, 5.0 mg/kg
Recovery of NK cytotoxicity capacity
Clinical demonstraion
- Participants : 83 healthy adults between the ages of 25 and 70
- Conditions : double-blind method, comparison after 8 weeks of ingestion
NK cell activation and increased levels of anti-inflammatory cytokine IL-10
Health functional food
| Type | Powder |
| Characteristics | Recognized by the Ministry of Food and Drug Safety as “May help improve immune function." |
| Application | Health functional food |
General food
| Type | Powder |
| Characteristics | Applied to immune improvement products and used in various products as sub-ingredients |
| Application | General food |
Feed ingredients
| Type | Powder, Liquid |
| Characteristics | Used as a natural feed additive, animal immunity-enhancing product, and feed efficiency-enhancing ingredient |
| Application | Immunological & nutritional enhancers |